Pesquisa sobre: MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS 
Descritores Encontrados: 1
Mostrando: 1 .. 1  

 1 / 1 DeCS     
Descritor Inglês:   Multidrug Resistance-Associated Proteins 
Descritor Espanhol:   Proteínas Asociadas a Resistencia a Múltiples Medicamentos 
Descritor Português:   Proteínas Associadas à Resistência a Múltiplos Medicamentos 
Sinônimos Inglês:   Multidrug Resistance-Associated Protein  
Categoria:   D12.776.157.530.100.304
D12.776.157.530.450.074.500.500.500
D12.776.543.585.100.304
D12.776.543.585.450.074.500.500.500
Definição Inglês:   A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins. 
Relacionados Inglês:   Drug Resistance, Multiple
P-Glycoproteins
 
Nota Histórica Inglês:   2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   36147 
Identificador Único:   D027425 

Ocorrência na BVS: 		 

Similar:
  
DeCS CID-10 SciELO LILACS LIS